NIDDK 2006 Urolithiasis Symposium

March 9-10, 2006 Wyndham Baltimore Inner Harbor Baltimore, MD

Agenda

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Thursday, March 9, 2006

7:55 a.m. - 8:00 a.m.

Welcome

Gary Curhan

8:00 a.m. - 10:00 a.m.

Clinical Management Oral Session

8:00 a.m. - 9:00 a.m.

Medical Management of Stone Disease

Moderator: David S. Goldfarb

	Future of trials in urolithiasis	Leroy Nyberg Jr. and John Kusek
	New medications for stone prevention	John Asplin
	Physiologic issues in the clinical management of calcium phosphate stones	Mitch Halperin
	Management of stones in the pediatric population	Craig Langman
	Long-term stone prevention: adherence and adverse effects of medications	David Goldfarb
	Pharmacogenomics and the Prevention of Stone Recurrence	Carla Monico

9:00 a.m. - 10:00 a.m.

Surgical Management of Stone Disease

Moderator: Martin Resnick

	Shokewave lithotripsy	James Lingeman
	Percutaneous nephrolithotomy	Steven Nakada
	Ureteroscopy	John Denstedt
	Laparoscopic approaches for renal and ureteral calculi	Stuart Wolf

10:00 a.m. - 10:10 a.m.

Comment Period for Clinical Management Session

10:10 a.m. - 10:30 a.m.

Break

10:30 a.m. - 11:45 a.m.

Imaging

Moderator: Dawn Milliner

	Preferred imaging modalities for stones	Bruce McClennan
	The future of stone imaging/New modalities to reduce radiation exposure	Cynthia McCollough
	Determination of stone composition and fragility by imaging	James C. Williams, Jr.

11:45 a.m. - 11:55 a.m.

Comment Period for Imaging Oral Session

12:00 noon - 1:00 p.m.

Lunch

1:00 p.m. - 2:00 p.m.

Critical Steps for Stone Formation

Moderator: Michael D. Ward

	Earliest phases of stone formation	Fred Coe
	Biomineralization of Uric Acid	Jennifer Swift
	Mechanisms of action of relevant urinary inhibitors	Jeff A. Wesson
	Cellular response to oxalate challenges	Julie Jonassen

2:00 p.m. - 2:10 p.m.

Comment Period for Stone Structure/Crystal
Attachment Oral Session

2:10 p.m. - 3:40 p.m.

Breakout Meetings *

Moderator

	Clinical management	Martin Resnick and David S. Goldfarb
	Imaging	Dawn Milliner
	Critical steps for stone formation	Michael Ward

3:40 p.m. - 4:00 p.m.

Break

4:00 p.m. - 5:15 p.m.

Pathophysiology

Moderator: Elaine Worcester

	Mechanisms of hypercalciuria	Fred Coe
	Uric acid and stone disease	Khashayar Sakhaee
	Obesity, bariatric surgery, and stone disease	Elaine Worcester
	Oxalate absorption and renal handling	David Mount
	Importance of citrate handling in stone disease	Patricia Preisig

5:15 p.m. - 5:25 p.m.

Comment Period for Pathophysiology

5:30 p.m.

Adjourn

Friday, March 10

7:30 a.m. - 8:30 a.m.

Animal Models

Moderator: John Lieske

	Models of hyperoxaluria: is any one preferred?	Neil Mandel
	What can models of hypercalciuria teach us about human nephrolithiasis?	David Bushinsky
	Other models of intrarenal crystal deposition	Jay Tischfield
	Newer genetic models of calcium stone disease	Xue-Ru Wu

8:30 a.m. - 8:40 a.m.

Comment Period

8:40 a.m. - 9:55 a.m.

Genetics/Genomics/Proteomics Oral Session

Moderator: Orson Moe

	Can transcriptional profiling help with understanding kidney stones?	Matthias Kretzler
	Should NIDDK have a core facility and database for nephrolithiasis research?	Erwin Bottinger
	The potential role of urinary proteomics in nephrolithiasis	John Arthur
	Application of proteomics in renal tissue from patients with nephrolithiasis	TBD

9:55 a.m. - 10:05 a.m.

Comment Period for Genetics/Genomics/Proteomics Oral Session

10:05 a.m. - 11:50 a.m.

Breakout Meetings *

Moderator

	Pathophysiology	Elaine Worcester
	Animal Models	John Lieske
	Genetics/genomics/proteomis	Orson Moe

11:50 a.m. - 12:50 p.m.

Presentation of Major Recommendations by Each Breakout Group

1:00 p.m.

Adjourn

* The breakout sessions will not have posters or talks. The goal is to have a discussion about the issues that will be raised during the talks and by the breakout moderators. A written document will be prepared from each breakout session describing the recommendations for future research in the area.