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  Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meetinge Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting  
Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting
Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting Nutrient Sensing, Insulin Singaling and Hamartoma Syndromes Meeting
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Day 1: Thursday, May 11, 2006
Session I Hamartoma Syndromes
1:30 p.m. Opening Remarks, NIH Program Directors
Dr. Griff Rodgers, Acting Director, National Institute of Diabetes, Digestive, and Kidney Diseases
Dr. Dinah Singer, Director, Division of Cancer Biology, National Cancer Institute
Dr. Steve Groft, Director, Office of Rare Diseases, National Institutes of Health
1:45 p.m. Keynote Address:
Tuberous Sclerosis from Mutations to Clinical Trials
Dr. Sandra Dabora, Harvard University
2:30 p.m. Phenomic Analysis of PTEN Hamartoma Tumor Syndromes
Dr. Charis Eng, Ohio State University
3:00 p.m. The LKB1 Kinase: Regulator of Tumorigenesis and Metabolism
Dr. Rueben Shaw, The Salk Institute
   
3:30 p.m. Coffee Break
   
Session II Insulin Signaling/mTOR
4:00 p.m. Keynote Address:
Insulin/IGF-1 Receptor/mTOR Signaling Pathway Perturbation in Disease
Dr. Tony Hunter, The Salk Institute
4:45 p.m. Activation of mTOR Complex 1 and Stimulation of eIF3-eIF4G Association by Insulin
Dr. John C. Lawrence, University of Virginia
5:15 p.m. The Role of the Nutrient Input in TSC1/2-Rheb Mediated mTOR Signaling
Dr. George Thomas, University of Cincinnati
   
5:45 p.m. Closing Remarks
   
Day 2: Friday, May 12, 2006
Session III Nutrient Sensing
8:00 a.m. Keynote Address:
Hamartoma Syndromes Result From Loss of Cell Intrinsic Sensors/Regulators of Bioenergetics
Dr. Craig Thompson, University of Pennsylvania
8:45 a.m. The Role of Akt in Energy Metabolism and the Genesis of Cancer
Dr. Nissim Hay, University of Illinois at Chicago
9:15 a.m. Regulation of Energy Metabolism and Growth of Prostate Cancer Cells by AMPK
Dr. Zhijun Luo, Boston University
   
9:45 a.m. Coffee Break
   
10:15 a.m. Insulin and Amino Acid Regulation pof TOR Complex 1 Through the Rheb GTPase
Dr. Joseph Avruch, Massachusetts General Hospital
10:45 a.m. Aberrant Cell Survival and Proliferation Signaling in TSC Cells and Tumors
Dr. Brendan Manning, Harvard University School
of Public Health
   
11:15 a.m. Late Breaking News
   
11:35 a.m. Drosophila Rheb, TOR, and TIF-IA
Dr. Bruce Edgar, Fred Hutchinson Cancer
Research Center
   
12:05 p.m. Lunch and Poster Viewing
   
Session III Nutrient Sensing (continued)
2:05 p.m. TORC1 Regulation by Hypoxia
Dr. James Brugarolas, Dana-Farber Cancer Institute
2:35 p.m. Mechanisms of REDD1 Signaling to mTOR
Dr. Leif Ellisen, Harvard University
   
3:05 p.m. Coffee Break
 
3:35 p.m. Late Breaking News
   
3:55 p.m. Regulation of and Signaling by the TORC1 Complex
Dr. John Blenis, Harvard University
4:25 p.m. Control of Cell Growth and Insulin Sensitivity by the TSC Tumor Suppressor Proteins
 Dr. Duojia (DJ) Pan, Johns Hopkins University School of Medicine
   
4:55 p.m. Closing Remarks and Adjournment
   
 

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This page last updated on 4/27/2006.