All sessions are to be chaired by Anna Moore, Martin Gotthardt, and Paul Harris. |
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| 8:45 a.m. - 11:30 a.m. |
Session I — Imaging Beta Cell Mass |
| 8:45 a.m. - 9:15 a.m. |
Keynote Address
Jacob Hald
Hagedorn Research Institute
Target Discovery and Antibody Production |
| 9:15 a.m. - 9:33 a.m. |
Maarten Brom
Radboud University Nijmegen Medical Center
Determination of the Beta-cell Mass by SPECT Imaging with 111In-DTPA-Exendin-3 in Rats |
| 9:33 a.m. - 9:51 a.m. |
Anne Grapin-Botton
Ecole Polytechnique Fédérale de Lausanne
Optical Coherence Microscopy of Endocrine Islets |
| 9:51 a.m. - 10:09 a.m. |
Stephan Schneider
Ruhr-University Bochum
Generation of Novel Single-chain Antibodies by Phage Display Technology to Direct Imaging Agents Highly Selective to Pancreatic Beta Cells In Vivo |
| 10:09 a.m. - 10:30 a.m. |
Break |
| 10:30 a.m. - 10:48 a.m. |
Daisy Flamez
Université Libre de Bruxelles
A Genomic-based Approach Identifies FXYD2γa as a Pancreatic Beta Cell Specific Biomarker |
| 10:48 a.m. - 11:06 a.m. |
Anna Moore
Harvard University
Noninvasive Imaging of Beta-cell Mass Using an Insulin-Specific Soluble T-cell Receptor |
| 11:06 a.m. - 11:16 a.m. |
Hot Topic: Is VMAT2 a Good Target?
Hank Kung
University of Pennsylvania
F-18 AV-133 as a Biomarker for Pancreas Beta Islet Cells |
| 11:16 a.m. - 11:26 a.m. |
Veronica Fagerholm
Turku PET Centre
[11C]DTBZ Exhibits High Non-Specific Binding in the Exocrine Pancreas |
| 11:26 a.m. - 11:50 a.m. |
Discussion:
Is VMAT2 a Good Target?
Can Ab Be Used for Imaging Beta Cells? |
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| 11:50 a.m. - 1:50 p.m. |
Lunch and Poster Viewing |
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| 1:50 p.m. - 3:30 p.m. |
Session II — Pancreatic Vasculature, Architecture, and Neuroregulation |
| 1:50 p.m. -2:20 p.m. |
Keynote Address
Leif Jansson
Uppsala University
Regulation of Pancreatic Islet Vasculature |
| 2:20 p.m. - 2:50 p.m. |
Keynote Address
Jesper Gromada
Novartis
Functional Consequences of Islet Innervation |
| 2:50 p.m. - 3:08 p.m. |
Alejandro Caicedo
University of Miami
The Anterior Chamber of the Eye Is a Viable Platform for the Study of Human Islet Cell Biology In Vivo |
| 3:08 p.m. - 3:26 p.m. |
Manami Hara
University of Chicago
Imaging and Quantification of Beta-cell Mass In Situ in Mice |
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| 3:26 p.m. - 5:30 p.m. |
Session III — Imaging of Islet Function |
| 3:26 p.m. - 3:44 p.m. |
M. Reza Mirbolooki
University of California at Irvine
18F-Fallypride PET to Monitor Pancreatic Islet Function |
| 3:44 p.m. - 4:02 p.m. |
Richard K.P. Benninger
Vanderbilt University
Quanitative Imaging and Modeling of Multi-cellular Interactions and Dynamics in the Islet |
| 4:02 p.m. - 4:20 p.m. |
Willy J. Malaisse
Université Libre de Bruxelles
Pancreatic Islet Structure and Function in LA/N-Cp Rats |
| 4:20 p.m. - 4:35 p.m. |
Break |
| 4:35 p.m. - 4:53 p.m. |
Brad Marsh
University of Queensland, Brisbane
Multi-resolution Spatio-temporal Analysis of the Insulin-secreting Beta Cell Reconstructed In Toto in Three Dimensions by Electron Tomography (ET) |
| 4:53 p.m. - 5:11 p.m. |
Muhammad E. Haque
University of Chicago
High Resolution and Multislice Functional MRI of Pancreatic Beta Cell Activation |
| 5:11 p.m. - 5:29 p.m. |
Patrick Antkowiak
University of Virginia
Toward Quantitation of Beta Cell Mass Using a Two Site Exchange Analysis of Manganese-Enhanced Magnetic Resonance Images |
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| Poster Session |
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| 5:30 p.m. - 7:00 p.m. |
Poster Viewing and Reception |
| 7:00 p.m. |
Adjourn |
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| Tuesday, April 7, 2009 |
| 7:30 a.m. - 8:30 a.m. |
Registration and Coffee |
| 8:30 a.m. – 8:35 a.m. |
Call to order and announcements |
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| 8:35 a.m. - 11:00 a.m. |
Session IV — Imaging of Islet Transplantation and Its Outcome |
| 8:35 a.m. - 9:05 a.m. |
Keynote Address
Bernhard J. Hering
University of Minnesota
Current State of Clinical Islet Transplantation |
| 9:05 a.m. - 9:23 a.m. |
Midhat Abdulreda
University of Miami
Live Noninvasive Imaging of Islet Allograft Rejection in the Anterior Chamber of the Eye |
| 9:23 a.m. - 9:41 a.m. |
Dian R. Arifin
Johns Hopkins University
Novel Trimodal Gadolinium-Gold Microcapsules for Simultaneous Immunoprotection and Positive Contrast MRI, X-ray, and Ultrasound Imaging of Human Pancreatic Islet Cells |
| 9:41 a.m. - 9:59 a.m. |
Taeho Kim
Seoul National University
Johns Hopkins University
Microfabrication of Multifunctional Alginate Capsule-in-Capsules (CICs) for Immunoprotected Cell Transplanation with MR, CT, and US Visibility |
| 9:59 a.m. - 10:20 a.m. |
Break |
| 10:20 a.m. - 10:38 a.m. |
Kannie W.Y. Chan
Johns Hopkins University
The University of Hong Kong
CEST Imaging of Microencapsulated Human Islets Allows Non-Invasive Assessment of Cell Viability |
| 10:38 a.m. - 10:56 a.m. |
Adriana Garcia
University of California at Irvine
18F-Fallypride MicroPET to Monitor Transplanted Islets in Diabetes Mellitus |
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| 11:00 a.m. - 3:30 p.m. |
Session V — Imaging of Islet Inflammation |
| 11:00 a.m. - 11:30 a.m. |
Keynote Address
Teresa DiLorenzo
Albert Einstein College of Medicine
What Is Islet Inflammation? |
| 11:30 a.m. - 12:00 p.m. |
Keynote Address
Caius Radu
University of California at Los Angeles
Novel PET Probes to Image the Immune System – From Discovery to Clinical Applications |
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| 12:00 p.m. - 2:00 p.m. |
Lunch and Poster Viewing |
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| 2:00 p.m. - 2:18 p.m. |
Alberto Signore
University of Groningen and University “Sapienza,” Rome
18F Interleukin-2, a Novel Radioactive Probe for Insulitis Imaging by PET |
| 2:18 p.m. - 2:36 p.m. |
Jason Gaglia
Harvard University and Joslin Diabetes Center
Noninvasive Imaging of Pancreatic Inflammation in Individuals With Type 1 Diabetes Using Magnetic Nanoparticle Enhanced Magnetic Resonance Imaging |
| 2:36 p.m. - 2:54 p.m. |
Zdravka Medarova
Harvard University
Magnetic Resonance Imaging of Microvascular Changes in Diabetic Rats |
| 2:55 p.m. - 3:15 p.m. |
Hot Topic Discussion:
Is Vascular Permeability a Good Biomarker for Pancreatic Inflammation? |
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| 3:15 p.m. - 5:00 p.m. |
Special Topic Talks and Panel Discussion |
| 3:15 p.m. - 3:30 p.m. |
Didier Laurent
Novartis
An Industrial Perspective on β-cell Imaging |
| 3:30 p.m. - 3:45 p.m. |
Nathalie Vercruysse
European Commission
European Funding Opportunities |
| 3:45 p.m. - 4:00 p.m. |
Bruce Schneider
Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA)
Regulatory Issues |
| 4:00 p.m. - 5:00 p.m. |
Panel Discussion |
| Panelists: |
Bruce Schneider, CBER, FDA
Didier Laurent, Novartis
Ann Jerkins, CADO, Center for Scientific Review (CSR), NIH
Eileen Bradley, MEDI-A, CSR, NIH
Maren Laughlin, NIDDK, NIH
Adrianne Wong, JDRF
Nathalie Vercruysse, European Commission |
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| 5:00 p.m. |
Adjourn |
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