Heme Regulation During Erythropoiesis - September 16

AGENDA

*Tuesday, September 16, 2008*

7:30 a.m. – 8:00 a.m.	Registration

8:00 a.m. – 8:15 a.m.	Welcoming Remarks Dr. Griffin Rodgers, Director, NIDDK

*I. Heme Biosynthesis*

8:15 a.m. – 9:00 a.m.	Heme Biosynthesis: An Overview and Introduction to the Workshop James Kushner, University of Utah

9:00 a.m. – 9:45 a.m.	In vivo Functional Analysis of Two 5-Aminolevulinate Synthase Isozymes and Heme Oxygenase-1 in Mouse Masi Yamamoto, Tohoku University

9:45 a.m. – 10:00 a.m.	Break

*II. Heme as a Cofactor and as a Regulator*

10:00 a.m. – 10:30 a.m.	Heme Is Required for MicroRNA Processing in Human Cells Feng Guo, University of California at Los Angeles School of Medicine

10:30 a.m. – 11:00 a.m.	Regulation of Gene Expression by Heme-Regulated eIF2α Kinase during Stress Erythropoiesis of Iron Deficiency Jane-Jane Chen, Massachusetts Institute of Technology

11:00 a.m. – 11:30 a.m.	Regulation of Gene Expression by Heme through Bach2 Kazuhiko Igarashi, Tohoku University

11:30 a.m. – 1:00 p.m.	LUNCH (on your own)

*III. Coordinate Regulation of Heme and Globin*

1:00 p.m. – 1:30 p.m.	Genomic Organization of Gene Expression during Hematopoiesis Mark Groudine, Fred Hutchinson Cancer Research Center

1:30 p.m. – 2:00 p.m.	An Erythroid Chaperone that Stabilizes the Heme Pocket of Bound Alpha Globin Mitch Weiss, Children’s Hospital of Philadelphia

2:00 p.m. – 2:30 p.m.	**hem6: an ENU-induced Recessive Hypochromic Microcytic Anemia Mutation in the Mouse** Mark Fleming, Children’s Hospital Boston

2:30 p.m. – 2:45 p.m.	Break

*IV. Heme Homeostasis and Trafficking*

2:45 p.m. – 3:15 p.m.	Studies of Heme Export, Heme-Iron Trafficking, and Erythropoiesis Jan Abkowitz, University of Washington

3:15 p.m. – 3:45 p.m.	Spatial Logistics for Enzymes of Heme Synthesis Harry Dailey, University of Georgia

3:45 p.m. – 4:15 p.m.	Mitoferrin1, a Solute Carrier, Is Essential for Mitochondrial Iron Acquisition during Vertebrate Erythropoiesis Barry Paw, Brigham and Women’s Hospital

4:15 p.m. – 4:45 p.m.	The Role of the Mitoferrins in Mammalian Mitochondrial Iron Metabolism Jerry Kaplan, University of Utah

4:45 p.m. – 5:15 p.m.	A Signal for Trafficking of ABCB6 and Other ABC Transporters John Schuetz, St. Jude Children’s Hospital

5:15 p.m. – 5:45 p.m.	Iron and Heme: Their Exquisite Relationship Makes Blood Red Prem Ponka, McGill University

6:00 p.m.	Dinner (on your own)

*Wednesday, September 17, 2008*

7:00 a.m. – 7:30 a.m.	Registration

7:30 a.m. – 8:30 a.m.	*** HOT TOPICS! ***

*V. Heme Catabolism*

8:30 a.m. – 9:00 a.m.	Heme Catabolism by Heme Oxygenase: A Pathway to Cytoprotection Karl Nath, Mayo Clinic

9:00 a.m. – 9:30 a.m.	Cerebral Malaria, Free Heme, Heme Oxygenase-1 and Carbon Monoxide: Shedding New Light on an Old Disease Maria Mota, Institute of Molecular Medicine, Portugal

9:30 a.m. – 9:45 a.m.	Break

*VI. Heme Dysregulation and Human Disease*

9:45 a.m. – 10:15 a.m.	Effects of a Mitochondrial Lesion on Red Cell Development Jeff Friedman, Scripps Institute

10:15 a.m. – 10:45 a.m.	Animal Models of Porphyria Robert Desnick, Mount Sinai School of Medicine

10:45 a.m. – 11:15 a.m.	Effective Gene Therapy of Congenital Erythropoietic Porphyria Mice is Facilitated by a Survival Advantage of Corrected Erythroid Cells Hubert de Verneuil, INSERM

11:15 a.m. – 12:30 p.m.	Summary and Adjournment (all registrants)