NIDDK-Sponsored Distribution Programs
- Liver Tissue Procurement and Distribution System (LTPADS)
- Availability Of Biologic Samples From Diabetic Study Population
Liver Tissue Procurement and Distribution System (LTPADS)
The Liver Tissue Procurement and Distribution System (LTPADS) is a National
Institutes of Health (NIH) service contract to provide human liver from regional
centers for distribution to scientific investigators throughout the United States.
These USA regional centers have active liver transplant programs with human
subjects' approval to provide portions of the resected pathologic liver for which
the transplant is performed. Frozen or fresh tissue is available from subcontractors
for the usual forms of childhood and adult cirrhosis, fulminant liver failure,
chronic rejection, and certain inborn errors of metabolism. Human pathologic
liver prepared according to the investigator's specifications provides the opportunity
to verify if animal liver investigations are relevant to human liver pathophysiology.
The preparation of these livers has been excellent for the usual molecular biologic
techniques for the past 10 years.
"Normal" liver specimens may be
requested; however, the supply is appropriately much more limited and completion
of proposal requests takes a longer time than for most pathologic liver specimens.
A new service is in the planning stage to provide isolated liver cells; thus we encourage
new proposals requesting hepatocytes from "normal" and/or pathologic human liver
obtained at the time of transplantation. NIH investigators are always given preference for
requests. Supporting letters for NIH new or renewal grant requests can be provided.
Further information, proposal forms, and requests for supporting letters can be obtained
from:
Harvey L. Sharp, M.D.
Principal Investigator, LTPADS
c/o Bobbie Randolph, Box 185 FUMC
University of Minnesota
Department of Pediatrics
Gastroenterology and Nutrition
420 Delaware Street S.E.
Minneapolis, MN 55455
Phone: (612) 624-1133
Fax: (612) 626-0639
Email: sharp001@tc.umn.edu
For more information, visit the LTPADS website.
Availability of Biologic Samples from Diabetic Study Population
(Notice released July 13, 1999)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces that a portion (1/3) of all stored non-renewable samples (plasma, serum, urine) from subjects enrolled in the Diabetes Control and Complications Trial (DCCT) is available for use by the scientific community to address questions for which these samples are uniquely invaluable.
For further information contact Catherine Cowie, Director, Type 1 Diabetes Clinical Trials Program, phone: (301) 594-8804, fax: (301) 480-3503, email: cowiec@extra.niddk.nih.gov.
A complete list of NIDDK patient recruitment activities is available
on the clinical
trials page.
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