Print Version |
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AGENDA |
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Organizers: Kip Guy, David Moore, Timothy Willson, Ron Margolis |
Day 1 – Thursday, April 16, 2009
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| 7:00 a.m. – 8:00 a.m. |
Registration and Continental Breakfast |
| 8:00 a.m. – 8:10 a.m. |
Welcome and Workshop Goals
Ronald Margolis, NIDDK |
| 8:10 a.m. – 8:50 a.m. |
Evolution of Receptor-ligand Interactions
Joe Thornton, University of Oregon |
| 8:50 a.m. – 10:20 a.m. |
Session 1: Binding at the Ligand Pocket (I) |
| 8:50 a.m. – 9:20 a.m. |
Estrogen Receptor: Ligand Regulation of Diverse Functions and In Vivo Imaging
John Katzenellenbogen
University of Illinois |
| 9:20 a.m. – 9:50 a.m. |
Chemical Rescue of Nuclear Receptor Mutations
John Koh
University of Delaware |
| 9:50 a.m. – 10:20 a.m. |
Design and Characterization of Selective Ligands for Thyroid Hormone Receptors
Thomas Scanlan
Oregon Health & Science University |
| 10:20 a.m. – 10:50 a.m. |
BREAK |
| 10:50 a.m. – 12:20 p.m. |
Session 2: Binding at the Ligand Pocket (II) |
| 10:50 a.m. – 11:20 a.m. |
Structural Basis of Binding and Selectivity of Nuclear Receptor Modulators
Ruben Abagyan
The Scripps Research Institute |
| 11:20 a.m. – 11:50 a.m. |
Cholesterol and Circadian Gating Control the Timing of Drosophila Metamorphosis via the Nuclear Receptors E75 and DHR3
Henry Krause
University of Toronto |
| 11:50 a.m. – 12:20 p.m. |
Structural Organization of the Intact PPARγ-RXRα Nuclear Receptor Complex on DNA
Fraydoon Rastinejad
University of Virginia Health Sciences System |
| 12:20 p.m. – 1:30 p.m. |
LUNCH BREAK (on your own) |
| 1:30 p.m. – 3:00 p.m. |
Session 3: Novel Technologies to Catalyze Progress |
| 1:30 p.m. – 2:00 p.m. |
Glucocorticoid Signaling Defines a Novel Commitment State During Adipogenesis In Vitro
Keith Yamamoto
University of California at San Francisco |
| 2:00 p.m. – 2:30 p.m. |
A Nuclear Receptor Library for Selectivity Profiling Within the MLPCN Network
Patrick Griffin
The Scripps Research Institute |
| 2:30 p.m. – 3:00 p.m. |
Small Molecule Transcriptional Switches
Anna Mapp
University of Michigan |
| 3:00 p.m. – 3:30 p.m. |
BREAK |
| 3:30 p.m. – 5:00 p.m. |
Session 4: Post-transcriptional Modification |
| 3:30 p.m. – 4:00 p.m. |
Post-translational Modifications of Coactivators in Physiology and Disease
Bert O’Malley
Baylor College of Medicine |
| 4:00 p.m. – 4:30 p.m. |
SUMOylation of Nuclear Receptors—A Potential Path to Regulate Those Obstinate Orphan Receptors
Holly Ingraham
University of California at San Francisco |
| 4:30 p.m. – 5:00 p.m. |
Functional Significance of Nuclear Receptor Acetylation
Richard Pestell
Thomas Jefferson University |
| 5:00 p.m. – 5:15 p.m. |
Late-breaking Stories |
| 5:00 p.m. – 5:15 p.m. |
High-content Imaging Methodologies to Quantify Nuclear Hormone Receptor Translocation and Co-activator Recruitment
Paul Johnston
University of Pittsburgh |
| 5:15 p.m. – 5:30 p.m. |
Synthetic Retinoid Agonists Induce Nuclear Receptor SHP Expression and SHP Translocation to Mitochondria to Activate Apoptosis and Inhibit Tumor Growth
Li Wang
University of Utah School of Medicine |
| 5:30 p.m. – 5:45 p.m. |
Amplification of Thyroid Hormone Signaling by Deiodinases is Critical During Adipogenesis
Antonio Bianco
University of Miami School of Medicine |
| 5:30 p.m. – 7:00 p.m. |
POSTER SESSION |
| 7:00 p.m. |
DINNER (on your own) |
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Day 2 – Friday, April 17, 2009 |
| 7:00 a.m. – 8:00 a.m. |
Registration and Continental Breakfast |
| 8:00 a.m. – 8:40 a.m. |
Systems Medicine – Methods for Mechanisms and Markers in Insulin Resistance
Shankar Subramaniam, University of California at San Diego |
| 8:40 a.m. – 10:10 a.m. |
Session 5: Metabolic Receptors and Xenobiotics |
| 8:40 a.m. – 9:10 a.m. |
Regulating the Human PXR Regulator in Liver and Intestinal Cells
Erin Schuetz
St. Jude Children's Research Hospital |
| 9:10 a.m. – 9:40 a.m. |
Endocrine Disruption and PPAR Activity: A Link to Obesity?
Beatrice Desvergne
University of Lausanne, Switzerland |
| 9:40 a.m. – 10:10 a.m. |
Antidiabetic Effects of Phospholipid LRH-1 Ligands
David Moore
Baylor College of Medicine |
| 10:10 a.m. – 10:30 a.m. |
BREAK |
| 10:30 a.m. – 12:00 p.m. |
Session 6: Coregulators: Structure/Function and
Role as Potential Target(s) |
| 10:30 a.m. – 11:00 a.m. |
Chemical Biology of the PGC-1 Coactivators
Bruce Spiegelman
Dana-Farber Cancer Institute and Harvard Medical School |
| 11:00 a.m. – 11:30 a.m. |
Differential Presentation of Protein Interaction Surfaces on the Androgen Receptor Defines the Pharmacological Actions of Bound Ligands
Donald McDonnell
Duke University Medical Center
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| 11:30 a.m. – 12:00 pm. |
Chemical Biology of Mitochondria
Vamsi Mootha
Harvard Medical School and Massachusetts General Hospital |
| 12:00 p.m. – 1:00 p.m. |
Session 7: Novel Approaches to the Clinic |
| 12:00 p.m. – 12:30 p.m. |
Modulation of the Thyroid Hormone Receptor to Attack Atherosclerosis, Obesity and Diabetes
John Baxter
The Methodist Hospital Research Institute
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| 12:30 p.m. – 1:00 p.m. |
Open Access Chemical Probes for Regulation of Gene Transcription
Timothy Willson
GlaxoSmithKline
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| 1:00 p.m. – 1:10 p.m. |
Meeting Summary and Future Directions
R. Kip Guy, St. Jude Children's Research Hospital |
| 1:10 p.m. |
Adjournment |
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