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| Monday, December 4, 2006 – Cabinet and Judiciary Rooms (Meeting Level) |
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| 7:00 a.m. |
Registration and Light Refreshments |
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| 8:00 a.m. |
Welcome and Aims
Jay Hoofnagle, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
National Institutes of Health (NIH) |
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SESSION 1: EPIDEMIOLOGY AND ETIOLOGY OF ACUTE LIVER FAILURE (ALF)
Moderators: Jay Hoofnagle, M.D., and William Bernal, M.D. |
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| 8:10 a.m. |
ALF: Overview of the Problem
William M. Lee, M.D.
University of Texas Southwestern Medical School |
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| 8:30 a.m. |
ALF: Evaluation and Management
Timothy Davern, M.D.
University of California at San Francisco |
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| 8:50 a.m. |
Natural History of ALF
Robert J. Fontana, M.D.
University of Michigan |
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| 9:10 a.m. |
Epidemiology of ALF in Children
Robert H. Squires, Jr., M.D.
Children’s Hospital of Pittsburgh, University of Pittsburgh |
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| 9:30 a.m. |
Discussion |
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| 10:00 a.m. |
Break |
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SESSION 2: LIVER TRANSPLANTATION (LT)
Moderators: Robert H. Squires, Jr., M.D., and Timothy Davern, M.D. |
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| 10:30 a.m. |
Issues in LT for ALF
Lorenzo Rossaro, M.D.
University of California at Davis Medical Center |
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| 10:50 a.m. |
Current Outcomes of LT for ALF
Robert M. Merion, M.D.
University of Michigan |
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| 11:10 a.m. |
Outcomes of Donors and Recipients Following Live Donor LT for ALF: A2ALL Study
James Trotter, M.D.
University of Colorado Health Sciences Center |
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| 11:30 a.m. |
LT for ALF in Children
John Bucuvalas, M.D.
Cincinnati Children’s Hospital |
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| 11:50 a.m. |
Discussion |
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| 12:20 p.m. |
Lunch (on your own) |
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SESSION 3: ACETAMINOPHEN
Moderators: William M. Lee, M.D., and Andres T. Blei, M.D. |
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| 1:20 p.m. |
Updates on the Pathophysiology of Acetaminophen Hepatotoxicity
Laura James, M.D.
University of Arkansas for Medical Sciences |
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| 1:40 p.m. |
Intentional Versus Unintentional Overdoses
Julie Polson, M.D.
University of Texas Southwestern Medical School |
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| 2:00 p.m |
Management of Acetaminophen Hepatoxicity
Anne Larson, M.D.
University of Washington |
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| 2:20 p.m. |
Acetaminophen: UK Experience
William Bernal, M.D.
Kings College Hospital, London, England |
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| 2:40 p.m. |
Discussion |
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| 3:10 p.m. |
Break |
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SESSION 4: MEDICAL THERAPY OF ALF
Moderators: Edward Doo, M.D., and Anne Larson, M.D. |
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| 3:40 p.m. |
Autoimmunity and ALF: Can Autoimmune Hepatitis be Distinguished from Indeterminate Etiologies?
R. Todd Stravitz, M.D.
Virginia Commonwealth University |
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| 4:00 p.m. |
Viral Causes of ALF
Anna S.F. Lok, M.D.
University of Michigan |
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| 4:20 p.m. |
Prevalence, Demographics, and Outcome of ALF at the Medical University of South Carolina
Adrian Reuben, M.D.
Medical University of South Carolina |
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| 4:40 p.m. |
Metabolic Causes of ALF
Ronald J. Sokol, M.D.
The Children’s Hospital, Denver |
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| 5:00 p.m. |
Discussion |
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| 5:30 p.m. |
POSTER SESSION – Congressional Room |
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| 7:00 p.m. |
Adjourn for the Day |
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| Tuesday, December 5, 2006 – Cabinet and Judiciary Rooms |
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| 7:00 a.m. |
Light Refreshments |
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| 8:00 a.m. |
Welcome and Overview
Organizers |
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SESSION 5: NON-SPECIFIC THERAPIES FOR ALF
Moderators: Robert Fontana, M.D., and Anna S.F. Lok, M.D. |
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| 8:10 a.m. |
Hypothermia for ALF
Andres T. Blei, M.D.
Northwestern University Feinberg School of Medicine |
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| 8:30 a.m. |
N-Acetylcysteine for ALF
William M. Lee, M.D.
University of Texas Southwestern Medical School |
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| 8:50 a.m. |
Plasmapheresis for ALF
Lars E. Schmidt, M.D., Ph.D.
Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark |
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| 9:10 a.m. |
Issues in Hepatic Assist Devices
John “Jack” F. Patzer, II, Ph.D.
University of Pittsburgh, McGowan Institute for Regenerative Medicine |
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| 9:30 a.m. |
Discussion |
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| 10:00 a.m. |
Break |
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SESSION 6: CELL FREE DEVICES
Moderators: Scott L. Nyberg, M.D., Ph.D., and Jorg C. Gerlach, M.D. |
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| 10:30 a.m. |
The Role of Extracorporeal Albumin Dialysis Using the Molecular Adsorbent Recirculating System in Patients with Liver Failure
Tarek Hassanein, M.D.
University of California at San Diego Medical Center |
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| 10:50 a.m. |
Plasma Filtration Therapy of ALF
Jacek Rozga, M.D., Ph.D.
Arbios Systems, Inc. |
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| 11:10 a.m. |
The Prometheus Filtration System
Michael P. Manns, M.D.
Hanover Medical School, Hanover, Germany |
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| 11:30 a.m. |
Discussion |
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| 12:00 p.m. |
Lunch (on your own) |
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SESSION 7: CELL-BASED DEVICES
Moderators: Jack Patzer, M.D., and William Lee, M.D. |
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| 1:00 p.m. |
Bioartificial Livers for ALF
Scott L. Nyberg, M.D., Ph.D.
Mayo Clinic |
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| 1:20 p.m. |
Three-Dimensional Perfusion Bioreactors for Human Progenitor Expansion and Provision of Cells for Liver Cell Transplantation
Jorg C. Gerlach, M.D.
University of Pittsburgh, McGowan Institute for Regenerative Medicine |
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| 1:40 p.m. |
Potential of Stem Cells for Bioartificial Liver
Lola M. Reid, Ph.D.
University of North Carolina at Chapel Hill School of Medicine |
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| 2:00 p.m. |
Hepatocyte Transplantation for ALF
Humberto E. Soriano, M.D.
St. Christopher’s Hospital for Children and Drexel University College of Medicine |
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| 2:20 p.m. |
Discussion |
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| 2:50 p.m. |
Break |
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SESSION 8: TISSUE ENGINEERING AND THE LIVER
Moderators: Christine A. Kelley, Ph.D., and Lola M. Reid, Ph.D. |
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| 3:20 p.m. |
Three-Dimensional Liver Models
Linda C. Griffith, Ph.D.
Massachusetts Institute of Technology |
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| 3:40 p.m. |
Synthetic Extracellular Matrices for 3-D Liver Regeneration
Glenn D. Prestwich, Ph.D.
The University of Utah |
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| 4:00 p.m. |
Liver Organ Engineering
Geoffrey Gurtner, M.D.
Stanford University |
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| 4:20 p.m. |
Discussion |
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| 5:00 p.m. |
Adjourn the Meeting |
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