Anion Transporters and Oxalate Homeostasis: From Genes to Diseases

Anion Transporters and Oxalate Homeostasis: From Genes to Diseases - December 8-9, 2008

DRAFT AGENDA
Day 1, Monday, December 8, 2008
12:00 – 1:00 p.m.	Registration
1:00 – 1:10 p.m.	Welcome and Introduction Robert Star, National Institute of Diabetes and Digestive and Kidney Diseases
1:10 – 2:00 p.m.	Keynote Address: Anion Channels and Transporters All Mixed Up Chris Miller, Brandeis University

Session 1: Transporters
2:00 – 2:25 p.m.	SLC26a Family in Gut and Kidney Manoocher Soleimani, University of Cincinnati
2:25 – 2:50 p.m.	Oxalate Transport Properties of SLC26A6 and SLC26 Polypeptide Orthologs From Human and Mouse Seth Alper, Beth Israel Deaconess Medical Center, Harvard Medical School
2:50 – 3:15 p.m.	Regulation of Slc26a6 Hatim Hassan, The University of Chicago
3:15 – 3:40 p.m.	Physiological Characterization of Epithelial Oxalate Exchangers David Mount, Brigham and Women’s Hospital
3:40 – 4:00 p.m.	BREAK
4:00 – 4:25 p.m.	The Sat1 (Slc26a1) Anion Transporter and Calcium Oxalate Urolithiasis Daniel Markovich, University of Queensland
4:25 – 4:50 p.m.	Diverse Transport Modes by the Solute Carrier 26 Family of Anion Transporters Shmuel Muallem, University of Texas Southwestern Medical Center
4:50 – 5:15 p.m.	Structure and Function of OxlT, the Oxalate Antiporter of Oxalobacter formigenes Peter Maloney, The Johns Hopkins University Medical School
5:15 – 5:30 p.m.	siRNA Knockdown of Slc26a6 Reveals the Contribution and Some Properties of PAT-1 to Transepithelial Anion Transport, Particularly Oxalate, Across Caco-2 Monolayers Robert Freel, University of Florida
5:45 p.m.	Reception

Day 2, Tuesday, December 9, 2008
Session 2: Oxalate Homeostasis
8:30 – 9:15 a.m.	Keynote Address: Identification of Small Molecules to Modulate Membrane Transport Alan Verkman, University of California, San Francisco
9:15 – 9:40 a.m.	Modulation of DRA Function and Expression by Gut Microbes Pradeep Dudeja, University of Illinois at Chicago
9:40 – 10:05 a.m.	Gut Oxalate Intake and Processing in Human Subjects Ross Holmes, Wake Forest University Medical School
10:05 – 10:20 a.m.	BREAK
10:20 – 10:45 a.m.	Oxalate Homeostasis—Insights From Knockout Mice Peter Aronson, Yale University School of Medicine
10:45 – 11:10 a.m.	Oxalate in the Kidneys of Human Stone Forming Patients Fred Coe, The University of Chicago

Session 3: Clinical Applications – Altering Oxalate Homeostasis
11:10 – 11:55 a.m.	Keynote Address: What Can We Learn from Bacteria? Jon Clardy, Ph.D., Harvard Medical School
11:55 – 1:05 p.m.	Lunch (on your own)
1:05 – 1:30 p.m.	*Physiological Interactions Between Oxalobacter* and the Transporting Mucosa** Marguerite Hatch, University of Florida
1:30 – 1:55 p.m.	Oxalobacter formigenes: A Potential New Therapy for Primary Hyperoxaluria Dawn Milliner, Mayo Clinic
1:55 – 2:20 p.m.	Oxalate Degrading Enzyme in Clinical Trials Kenneth Attie, Altus Pharmaceuticals
2:20 – 2:30 p.m.	Identification, Cloning, and Characterization of Human 2-Keto-4-Hydroxy-Glutarate Aldolase (KHGA), an Attractive Therapeutic Target to Block the Production of Glyoxylate From Hydroxyproline Catabolism Travis Riedel, Wake Forest University School of Medicine
2:30 – 2:55 p.m.	*The Epidemiology of Oxalobacter formigenes* and Its Relation to Kidney Stones** Judith Kelly, Boston University School of Medicine
2:55 – 3:20 p.m.	Human SLC26A6 Variation in Oxalate Homeostasis Carla Monico, Mayo Clinic
3:20 p.m.	Adjournment

DRAFT AGENDA

Day 1, Monday, December 8, 2008

Day 2, Tuesday, December 9, 2008