The Interface Between the Nervous and the Immune System in the Pathogenesis of Autoimmune Diabetes - June 15, 2011 - Neuroscience Center (NSC) Building
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AGENDA

Co-chairs:  Alejandro Caicedo, Ph.D.; Hans-Michael Dosch, M.D., Ph.D.; and Gerald Taborsky, Jr., Ph.D.

   
7:30 – 8:00 a.m. Registration
   

Introductory Lecture

   
8:00 – 8:30 a.m.

Histopathology of Type 1 Diabetes in Pancreata from Cadaveric Organ Donors Objectives
Matthias von Herrath, M.D., Ph.D.

   

Session A:  Influence of the Nervous System on Immune Responses—Possible Implications for Autoimmune Diabetes
Chair:         Hans-Michael Dosch, M.D., Ph.D.

   
8:30 – 9:00 a.m.

A Role for Sensory Nerves in Islet Immune Responses
Hans-Michael Dosch, M.D., Ph.D.

   
9:00 – 9:30 a.m.

Neurons:  Major Negative Regulators of Activated T cells
Shohreh Issazadeh-Navikas, Ph.D.

   
9:30 – 10:00 a.m.

Glutamate as a Regulator of Adaptive Immunity
Ursula Grohmann, Ph.D.

   
10:00 – 10:15 a.m. Break
   
10:15 – 10:45 a.m.

The Inflammatory Reflex
Kevin Tracey, M.D.

   
10:45 – 11:15 a.m. Sympathetic-Immune Modulation and Autoimmunity:  Lessons Learned from Autoimmune Arthritis
Denise Bellinger, Ph.D.
   
11:15 – 11:45 a.m.   Questions and Roundtable Discussion
   
11:45 a.m. – 12:45 p.m. Lunch (on your own)
   

Session B:  Neural Dysfunction in Diabetes
Chairs:       Alejandro Caicedo, Ph.D. and Gerald Taborsky, Jr., Ph.D.

   

Introductory Lectures

   
12:45 – 1:15 p.m.

Neural Control of the Pancreatic Islet
Alejandro Caicedo, Ph.D.

   
1:15 – 1:45 p.m.

Serotoninergic Pathways and ß cell Proliferation/Regeneration
Michael German, M.D.

   

Session B1:  Islet Neural Dysfunction in Diabetes:  Role of Autoimmunity
Chair:           Alejandro Caicedo, Ph.D.

   
1:45 – 2:15 p.m. Peri-Islet Glia in Autoimmune Type 1 Diabetes
Hubert Tsui, Ph.D.
   
2:15 – 2:45 p.m.

Immune Mediated Loss of Islet Sympathetic Nerves and Impairment of Glucagon Secretion
Gerald Taborsky, Jr., Ph.D.

   
2:45 – 3:15 p.m.

ß Lymphocyte Autoimmune Response to Nervous System Elements in the Course of Type 1 Diabetes
Joan Verdaguer, M.D., Ph.D.

   
3:15 – 3:30 p.m. Break
   

Session B2:  Neural Dysfunction in Diabetes:  Role of Insulin Deficiency and Hyperglycemia
Chair:           Gerald Taborsky, Jr., Ph.D.

   
3:30 – 4:15 p.m.

Dysfunction of the Hypothalamic-Islet Axis in Diabetes
Robert Sherwin, M.D.

   
4:15 – 4:45 p.m.

Vagal Contribution to Metabolic Homeostasis in Humans
Karen Teff, Ph.D.

   
4:45 – 5:15 p.m.

Diabetes-induced Dysfunction of Ganglionic Neurotransmission
Ellis Cooper, Ph.D.

   

Final Discussion

   
5:15 p.m.

Therapeutic Implications
Possible Research Initiatives in This Field

   
NIDDK NIH DHHS