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Tuesday, March 25, 2008 |
| 7:30 – 7:50 a.m. |
Continental Breakfast |
| 7:50 – 8:00 a.m. |
Introductions and Logistics
Jill Carrington |
| 8:00 – 8:20 a.m. |
Welcome
Griffin Rodgers, Director, National Institute of Diabetes and Digestive and Kidney Diseases |
The Epithelial Barrier in the Intestine
Asma Nusrat, Chair, Emory University |
| 8:20 – 8:35 a.m. |
The Epithelial Barrier in the Intestine – Introduction
Asma Nusrat, Emory University |
| 8:35 – 9:00 a.m. |
Mechanisms Regulating Epithelial Cell Surface Polarity
W. James Nelson, Stanford University |
| 9:00 – 9:25 a.m. |
Structure and Properties of the Paracellular Barrier
James M. Anderson, University of North Carolina at Chapel Hill |
| 9:25 – 9:50 a.m. |
Paneth Cell Biology in Barrier Function
Andre Ouellette, University of California, Irvine |
| 9:50 – 10:05 a.m. |
Discussion
Speaker Panel |
| 10:05 – 10:15 a.m. |
Break |
Normal Epithelial Replacement and Healing
Deborah Rubin, Chair, Washington University |
| 10:15 – 10:30 a.m. |
Normal Epithelial Replacement and Healing – Introduction
Deborah Rubin, Washington University |
| 10:30 – 10:55 a.m. |
The Epithelium as a Detector and a Director of Tissue Patterning In Health and Disease: Role of the Hedgehog Signaling Pathway
Deborah Gumucio, University of Michigan Medical School |
| 10:55 – 11:20 a.m. |
Environmental Effects on Healing, Myofibroblasts
Don Powell, The University of Texas Medical Branch |
| 11:20 – 11:45 a.m. |
Cell-Matrix Interactions and Epithelial Functions
Jean-François Beaulieu, Université de Sherbrooke |
| 11:45 – 12:50 p.m. |
Lunch |
| Normal Epithelial Replacement and Healing, continued |
| 12:50 – 1:15 p.m. |
The Influence of Commensal Bacteria on NFkB Signaling and Mucosal Homeostasis
Balfour Sartor, University of North Carolina at Chapel Hill |
| 1:15 – 1:40 p.m. |
Wnt-Dependent ex vivo Expansion of Primary Intestinal Progenitors
Calvin Kuo, Stanford University |
| 1:40 – 2:05 p.m. |
Importance of RB and Wnt Signaling for Differentiation of Enteroendocrine Cells
Andrew Leiter, University of Massachusetts Medical School |
| 2:05 – 2:25 p.m. |
Neuropeptides and Intestinal Mucosal Healing
Charalabos Pothoulakis, University of California, Los Angeles |
| 2:25 – 2:45 p.m. |
Discussion
Speaker Panel |
| 2:45 – 3:00 p.m. |
Break |
Stem Cell Biology of the Intestine
Linheng Li, Chair, Stowers Institute for Medical Research |
| 3:00 – 3:15 p.m. |
Stem Cell Biology of the Intestine – Introduction
Linheng Li, Stowers Institute for Medical Research |
| 3:15 – 3:40 p.m. |
Stem Cells, Niches, and Zones
Linheng Li, Stowers Institute for Medical Research |
| 3:40 – 4:05 p.m. |
Decision Pathways for Tissue Differentiation and Metaplasia
Ramesh Shivdasani, Dana-Farber Cancer Institute |
| 4:05 – 4:30 p.m. |
The Challenge of Stem Cell Isolation and Characterization
Susan Henning, University of North Carolina at Chapel Hill |
| 4:30 – 4:55 p.m. |
Adaptation of the Intestinal Stem Cell Niche
Thaddeus Stappenbeck, Washington University |
| 4:55 – 5:15 p.m. |
Discussion
Speaker Panel |
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Wednesday, March 26, 2008 |
| 7:30 – 8:00 a.m. |
Continental Breakfast |
Effects of the Inflammatory Environment on the Epithelium
Richard Blumberg, Chair, Harvard Medical School |
| 8:00 – 8:15 a.m. |
Effects of the Inflammatory Environment on the Epithelium – Introduction
Richard Blumberg, Harvard Medical School |
| 8:15 – 8:40 a.m. |
ER Stress of the Intestinal Epithelium and Inflammation
Richard Blumberg, Harvard Medical School |
| 8:40 – 9:05 a.m. |
Genetics of Barrier Integrity and Disease Susceptibility
John Rioux, Université de Montréal and Montreal Heart Institute |
| 9:05 – 9:30 a.m. |
Leukocyte-Epithelial Interactions
Charles Parkos, Emory University |
| 9:30 – 10:00 a.m. |
Break |
| Effects of the Inflammatory Environment on the Epithelium, continued |
| 10:00 – 10:25 a.m. |
The Intestinal Epithelium: Balancing Immunity and Inflammation in the Gut
David Artis, University of Pennsylvania |
| 10:25 – 10:50 a.m. |
The Role of an Inflammatory Microenvironment on Epithelial Regeneration
Melissa Wong, Oregon Health and Science University |
| 10:50 – 11:15 a.m. |
Mechanisms of Beta-Catenin Signaling in Colitis-Induced Cancer
Jeffery Brown, Children’s Memorial Hospital |
| 11:15 – 11:35 a.m. |
Discussion
Speaker Panel |
| 11:35 – 12:45 p.m. |
Lunch |
Inflammation and Cancer
Charles Parkos, Chair, Emory University |
| 12:45 – 1:00 p.m. |
Inflammation and Cancer – Introduction
Charles Parkos, Emory University |
| 1:00 – 1:25 p.m. |
Role of TRLs in Promoting Colorectal Cancer
Maria Abreu, University of Miami |
| 1:25 – 1:50 p.m. |
Tumor Stroma Stimulation of Immune Responses
Derek Radisky, Mayo Clinic Jacksonville |
| 1:50 – 2:15 p.m. |
A Novel Mechanism of Colon Cancer Invasion: The Role of CCR and Myeloid Cells
Makoto M. Taketo, Kyoto University |
| 2:15 – 2:35 p.m. |
Discussion
Speaker Panel |
| 2:35 – 3:30 p.m. |
Future Research Directions – Final Discussion
Participants |
| 3:30 p.m. |
Adjournment |
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