DRAFT AGENDA |
| Tuesday, May 5, 2009 |
| 7:30 – 8:00 a.m. |
Registration and Continental Breakfast |
| 8:00 – 8:05 a.m. |
Welcome and Opening Remarks
Griffin Rodgers, M.D., NIDDK or Judith Fradkin, M.D., NIDDK |
| 8:05 – 8:25 a.m. |
Introduction
Jerry Palmer, M.D., University of Washington |
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A. Innate and Adaptive Immunity in the Pathogenesis of Metabolic Disorders |
A1. Systems and Cells
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| 8:30 – 8:50 a.m. |
Innate Control of the Adaptive IR, Relationship With Inflammation, and Autoimmunity: A Systems Approach to Dissecting Immunity
Alan Aderem, Ph.D., Institute for Systems Biology |
| 8:55 – 9:15 a.m. |
Macrophage Non Opsonic Receptors and Inflammation
Siamon Gordon, Ph.D., University of Oxford |
| 9:20 – 9:40 a.m. |
Interactions of Innate and Adaptive Immunity With Blood Vessels
Jordan Pober, M.D., Ph.D., Yale University School of Medicine |
| 9:45 – 10:05 a.m. |
Adaptive Control of Innate Immunity
Diane Mathis, Ph.D., M.Sc., The Harvard Stem Cell Institute |
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| 10:05 – 10:20 a.m. |
Break |
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A2. Mediators and Mechanisms
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| 10:20 – 10:40 a.m. |
iNKT Cells and Diabetes
Luc Van Kaer, Ph.D., Vanderbilt University School of Medicine |
| 10:45 – 11:05 a.m. |
The NLR (NBD-LRR) Gene Family
Jenny Ting, Ph.D., University of North Carolina at Chapel Hill |
| 11:10 – 11:30 a.m. |
Novel Mediators in Resolution of Inflammation
Charles N. Serhan, Ph.D., Brigham and Women’s Hospital |
| 11:35 – 11:55 a.m. |
Session A Roundtable Discussion |
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| 11:55 – 1:00 p.m. |
Lunch (On Your Own) |
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B1. Systemic Inflammation and Insulin Resistance: Common Features in Animal Models and Patients
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| 1:00 – 1:20 p.m. |
T1D-T2D Common Factors/Differences in Animals and Patients
Massimo Pietropaolo, M.D., University of Michigan |
| 1:25 – 1:45 p.m. |
Autoimmunity, Inflammation, and Insulin Resistance in T1D
Maria Koulmanda, Ph.D., Harvard University |
| 1:50 – 2:10 p.m. |
The Immune Response: Inflammation and Insulin Resistance in T2D
Gokhan Hotamisligil, M.D., Ph.D., Harvard School of Public Health |
| 2:15 – 2:35 p.m. |
Immune Response, Inflammation, and Adipose Tissue
Anthony Ferrante, M.D., Ph.D., Columbia University |
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| 2:40 – 2:55 p.m. |
Break |
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| 2:55 – 3:15 p.m. |
Immunology in Obesity and T2D: IKK-NfKB
Steven Shoelson, M.D., Ph.D., Joslin Diabetes Center |
| 3:20 – 3:40 p.m. |
Foxos: Overlapping Regulators in T2D and Immunity
Stephen M. Hedrick, Ph.D., University of California at San Diego |
| 3:45 – 4:05 p.m. |
PTPases Linking Autoimmunity/Metabolic Syndrome: Small Molecule Inhibitors
Nunzio Bottini, M.D., University of Southern California |
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| 4:10 – 4:25 p.m. |
Break |
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B2. Potential Targets and Therapies
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| 4:25 – 4:45 p.m. |
The Anti-inflammatory and Cardioprotective Effect of Insulin and the Pro-inflammatory Effect of Glucose, FFAs, and Macronutrients
Paresh Dandona, M.D., D.Phil., State University of New York at Buffalo and Kaleida Health |
| 4:50 – 5:10 p.m. |
Anti-inflammatory Modulation Insulin Resistance: TINSAL-T2D
Allison Goldfine, M.D., Harvard Medical School |
| 5:15 – 5:45 p.m. |
Session B Roundtable Discussion |
| 5:45 p.m. |
Adjournment |
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Wednesday, May 6, 2009 |
| 7:30 – 8:00 a.m. |
Registration and Continental Breakfast |
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C. Convergence of Inflammation and Autoimmunity on the Beta Cell |
C1. Autoimmunity
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| 8:00 – 8:20 a.m. |
Toll-like Receptors and T-Cell Anti-Beta-Cell Immunity
Susan Wong, Ph.D., University of Bristol |
| 8:25 – 8:45 a.m. |
Immune and Inflammatory Origin of T2D
Hubert Kolb, Ph.D., University of Düsseldorf |
C2. Beta Cell Demise and Death Pathways
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| 8:50 – 9:10 a.m. |
Molecular Pathways in Inflammatory Beta-Cell Destruction
Thomas Mandrup-Poulsen, MD., Ph.D., Steno Diabetes Center |
| 9:15 – 9:35 a.m. |
Insulitis and Beta-Cell Failure in T2D: Basic and Clinical Aspects
Marc Donath, M.D., University Hospital of Zürich |
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| 9:40 – 10:00 a.m. |
Break |
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| 10:00 – 10:20 a.m. |
Systems Approaches to Determine the Basis for Beta Cell Death by ER Stress
Fumihiko Urano, Ph.D., University of Massachusetts Medical School |
| 10:25 – 10:45 a.m. |
Role of ER Stress in Beta Cell Dysfunction in T2D
Randall Kaufman, Ph.D., University of Michigan Medical School |
| 10:50 - 11:10 a.m. |
Intracellular Pathways of Beta Cell Apoptosis
Helen Thomas, Ph.D., St. Vincent’s Institute |
| 11:15 – 11:35 a.m. |
The Regulation of Pancreatic Beta Cell Death
Kenneth Polonsky, M.D., Washington University |
| 11:35 – 11:55 a.m. |
Session C Roundtable Discussion |
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| 12:00 – 1:00 p.m. |
Lunch (On Your Own) |
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| D. Lessons From Other Diseases |
| 1:00 – 1:20 p.m. |
Common Allelic Variants in Human Autoimmune Disease
David Hafler, M.D., Harvard Medical School |
| 1:25 – 1:45 p.m. |
Mast Cell Regulation of Tolerance and Immunity
Randolph Noelle, Ph.D., Dartmouth Medical School |
| 1:50 – 2:30 p.m. |
Discussion: Development of Priorities and Next Steps |
| 2:30 p.m. |
Adjournment |
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