AGENDA

Organizing Committee: Dr. Russell Chesney, The University of Tennessee (Co-Chair); Dr. Linda M. Dairiki Shortliffe, Stanford University School of Medicine (Co-Chair); Dr. Debbie Hoshizaki, NIDDK, National Institutes of Health (NIH); Dr. Marva Moxey-Mims, NIDDK, NIH; Dr. Rebekah Rasooly, NIDDK, NIH Monday, December 7, 2009

7:30 – 8:30 a.m.	*Registration*

8:30 – 9:15 a.m.	Introductions and Welcome Keynote Address: Normal Embryology and Development Using Mouse Models to Investigate the Basis of Lower Urinary Tract Birth Malformations Cathy Mendelsohn, Ph.D.,Columbia University

9:15 – 10:45 a.m.	Session 1: Genetics of GU Development Distal Ureter Maturation in Development and Disease Maxime Bouchard, Ph.D., McGill University, Montreal, Quebec, Canada Studies of Ureter and Ureteropelvic Junction Development Doris Herzlinger, Ph.D., Weill Medical College of Cornell University Molecular Genetic Study of Congenital Urinary Tract Obstruction Feng Chen, Ph.D., Washington University School of Medicine Hox10 Genes are Required for the Differentiation and Integration of Kidney Cortical Stroma Cells Deneen Wellik, Ph.D., University of Michigan

10:45 – 11:00 a.m.	*Break*

11:00 a.m. – 12:30 p.m.	Session 2: Genetics of Primary VUR – Animal Models Using the Mouse to Define VUR Phenotypes Indra Gupta, Ph.D., McGill University, Montreal, Quebec, Canada Robo2 Gene and Vesicoureteral Reflux Weining Lu, M.D., Boston Medical Center Smooth Muscle Dysplasia of the Ureter Adrian Woolf, University College London, United Kingdom Urothelial Defects and VUR Tung-Tien Sun, Ph.D., New York University School of Medicine

12:30 – 1:30 p.m.	*Lunch (on your own)*

1:30 – 2:15 p.m.	Keynote Address Finding Genes for Rare Mendelian Disorders: Hypophosphatemia Harald Jueppner, M.D., Harvard Medical School

2:15 – 3:20 p.m.	Session 3: Consequences of Obstruction Genetic Risk Factors for Vesicoureteral Reflux and Renal Scarring: What is truly at Stake? Hans Pohl, M.D., Children’s National Medical Center Host—Pathogen Interactions During Bladder Infections Soman Abraham, Ph.D., Duke University School of Medicine Molecular Consequences of Unilateral Ureteral Obstruction Robert Chevalier, M.D., University of Virginia

3:20 – 3:35 p.m.	*Break*

3:35 – 5:00 p.m.	GUDMAP and Finding Genes for Diseases GUDMAP – A Gene Expression Resource for Investigation of Candidate Disease Genes in Urologic Disorders Michelle Southard-Smith, Ph.D., Vanderbilt University Investigation of Candidate Disease Genes in Urologic Disorders Bruce Aronow, Ph.D., Cincinnati Children’s Hospital Medical Center

5:00 p.m.	*Adjourn for the day*

Tuesday, December 8, 2009

8:00 – 8:30 a.m.	*Registration*

8:30 – 9:15 a.m.	Keynote Address Epigenetics in Development Greg Dressler, Ph.D., University of Michigan

9:15 – 10:30 a.m.	Session 4: Genetics of Primary VUR and CAKUT – Human Genetics Genetics of Primary VUR Ali Gharavi, M.D., Columbia University Searching for VUR Genes in an Irish Cohort David Barton, Ph.D., National Centre for Medical Genetics, Dublin, Ireland Identification of Recessive CAKUT Genes by Homozygosity Mapping, Exon Capture, and Large-scale Sequencing Friedhelm Hildebrandt, M.D., Howard Hughes Medical Institute and University of Michigan

10:30 – 10:45 a.m.	*Break*

10:45 a.m. – 11:45 a.m.	Session 5: Patient Collections for VUR Genetics RIVUR Saul Greenfield, M.D., The State University of New York at Buffalo CKiD Susan Furth, M.D., Ph.D., Johns Hopkins University School of Medicine Patricia Weng, M.D., Columbia University Harald Jueppner, M.D., Harvard Medical School Sanjay Jain, M.D., Ph.D., Washington University in St. Louis School of Medicine David Hains, M.D., Nationwide Children’s Hospital

11:45 a.m. – 1:00 p.m.	Session 6: Planning for Genetic Studies of VUR Moderated Discussion/Breakout Groups W. Linda Kao, Ph.D., Johns Hopkins University School of Public Health Braxton Mitchell, Ph.D., University of Maryland School of Medicine

1:00 p.m.	*Adjournment*