DRAFT AGENDA |
Monday, April 21, 2008 |
| 8:30 – 8:45 a.m. |
Welcome
Griffin Rodgers, Director, NIDDK
Meeting Objectives
Catherine McKeon and Michael Appel, NIDDK |
| 8:45 – 10:30 a.m. |
Introductory Lectures
New Discoveries in the Risk Loci for Type 2 Diabetes
David Altshuler, Massachusetts General Hospital
How Does a ß-Cell Work and How Might It Go Wrong?
Christopher Rhodes, University of Chicago |
| 10:30 – 10:45 a.m. |
Break |
| 10:45 – 10:50 a.m. |
Session 1: Type 2 Diabetes and the Islet ß-Cell
Chairman: Christopher Rhodes, University of Chicago |
| 10:50 – 11:10 a.m. |
ß-Cell Lineage and Notch 2 Genes in the Endocrine Pancreas
Christopher Wright, Vanderbilt University Medical Center |
| 11:10 – 11:30 a.m. |
Co-Opting Cell Cycle Control Mechanisms for Inducing Pancreatic β-Cell Replication
Andrew Stewart, University of Pittsburg |
| 11:30 – 11:50 a.m. |
Cell Cycle Factors Influencing Islet β-Cell Decline and Apoptosis
Norman Sharpless, University of North Carolina School of Medicine |
| 11:50 a.m. – 12:10 p.m. |
Understanding β-Cell Loss in Type 2 Diabetes — the Relevance of Animal Models
Peter Butler, University of California at Los Angeles |
| 12:10 – 12:30 p.m. |
Discussion: Experimental Approaches to Measurement of Human Islet ß-Cell Mass and Modeling Strategies for Inducing ß-Cell Recovery |
| 12:30 – 1:30 p.m. |
Lunch (on your own) |
| 1:30 – 1:35 p.m. |
Session 2: Insulin Secretion and Defects in Type 2 Diabetes
Chairman: Domenico Accili, Columbia University |
| 1:35 – 1:55 p.m. |
The Islet ß-Cell and Insulin Resistance
Domenico Accili, Columbia University |
| 1:55 – 2:15 p.m. |
KATP Channel Mutations in Congenital Diabetes: Bench-to-Bedside
Joseph Bryan, Pacific Northwest Research Institute |
| 2:15 – 2:35 p.m. |
ZnT8 (Slc 30A8) — A Major Autoimmune Target in Type 1 Diabetes Is Associated with Type 2 Diabetes. Is There a Connection?
John Hutton, University of Colorado Health Sciences Center |
| 2:35 – 2:55 p.m. |
NAD World: A New Systemic Network for the Regulation of Metabolism and Aging in Mammals: Sirt1, Systemic NAD Biosynthesis and Their Importance
Shinichiro Imai, Washington University in St. Louis |
| 2:55 – 3:15 p.m. |
Discussion: Newly Discovered Diabetes Genes — Contributions to Insulin Secretion? |
| 3:15 – 4:15 p.m. |
Poster Viewing |
| 4:15 – 5:15 p.m. |
Oral Poster Presentations (selection of six for 10 minutes each) |
| 5:15 p.m. |
Adjournment (evening free) |
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Tuesday, April 22, 2008 |
| 8:30 – 8:35 a.m. |
Session 3: Diabetes Risk Genes and Diabetes Phenotypes
Chairman: Robert Hanson, NIDDK |
| 8:35 – 8:55 a.m. |
IMP2 — Role in Type 2 Diabetes
Joseph Avruch, Massachusetts General Hospital |
| 8:55 – 9:15 a.m. |
Islet Transcriptional Factors, Islet Vasculature and Insulin Secretion Vasculature
Alvin Powers, Vanderbilt University |
| 9:15 – 9:35 a.m. |
Diabetes Genes and the Progression to Diabetes — Lessons from the Pima Indians
Robert Hanson, NIDDK |
| 9:35 – 9:55 a.m. |
Diabetes Genes, Progression to Diabetes and Response to Preventive Interventions — Lessons from the DPP
Jose Florez, Massachusetts General Hospital |
| 9:55 – 10:10 a.m. |
Discussion: Newly Discovered Diabetes Genes — Their Contribution to Disease Severity, Progression, and Treatment |
| 10:10 – 10:30 a.m. |
Break |
| 10:30 – 10:35 a.m. |
Session 4: Linking Diabetes Risk Genes with Functional Expression
Chairman: David Altshuler, Massachusetts General Hospital |
| 10:35 – 10:55 a.m. |
Integration of Diabetes Risk Genetics with Functional Expression
Alan Attie, University of Wisconsin |
| 10:55 – 11:15 a.m. |
Transcriptomic Approaches to Identification of Genes Identifying Diabetes Risk
Joanne Curran, Southwest Foundation for Biomedical Research |
| 11:15 – 11:45 a.m. |
Panel Discussion: Moving from SNPs to Function
Discussants: David Altshuler, Alan Attie, Joanne Curran, Joseph Avruch, Christopher Rhodes, Domenico Accili |
| 11:45 a.m. – 12:15 p.m. |
Workshop Perspectives — Gene Signatures and the ß-Cell
Steven Kahn, DVA Puget Sound Health Care System |
| 12:15 p.m. |
Adjournment |
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