DRAFT AGENDA |
Sunday, September 25, 2011 |
| 5:45 p.m. – 6:00 p.m. |
Welcome and NIDDK Priorities
Griffin Rodgers
Director, National Institute of Diabetes and Digestive and Kidney Diseases |
| 6:00 p.m. – 6:10 p.m. |
Welcome and Review of Meeting Objectives and Agenda
Stephen James |
| 6:10 p.m. – 7:30 p.m. |
Session I: Acute Diarrhea: Current Understanding and Challenges
Moderator: James Nataro
Epidemiology, Risk Factors, Clinical Manifestations, and Outcomes
Sean Moore
Current Pharmacology and Unmet Medical Needs
Henry J. Binder
Therapeutic Challenges and Translational Approaches to Diarrhea Prevention and Treatment in Under-Developed Nations
Olivier Fontaine
Primary Discussant
David A. Sack
Panel Discussion |
| |
|
Monday, September 26, 2011 |
| 8:30 a.m. – 10:35 a.m. |
Session II: Pathogenesis
Moderator: Gail Hecht
Common Pathways in Pathogenesis: Clues for Potential Targets
Kim Barrett
Inflammatory Bacterial Diarrhea: Inflammatory and Immune Mediators and Epithelial Damage
Gail Hecht
Toxin-Mediated Bacterial Diarrheas
Wayne Lencer
Viral Diarrheal Diseases
Mary K. Estes
Host Response to Acute Diarrhea Due to Parasites
William A. Petri
Impact of Intestinal Microbiota on Pathogen Susceptibility
James Versalovic
Primary Discussant: Novel Approaches to Oral Rehydration and Nutrition Therapy (ORNT)
Richard Guerrant
Panel Discussion |
| 10:35 a.m. – 11:00 a.m. |
BREAK |
| 11:00 a.m. – 5:45 p.m. |
Session III: Pathophysiologic Mechanisms |
| 11:00 a.m. – 12:45 p.m. |
Session III A: Transporters and Channels
Moderator: James Anderson
Overview of Pathophysiologic Mechanisms
Mark Donowitz
Preclinical Models: From Cultured Cells and Organoids to Animal Models and Biopsies
Hugo de Jonge
Overview of the Role of Cl channels
Nadia Ameen
Role of CFTR vs Calcium-Activated Chloride Channels in Intestinal Cl Secretion
Alan Verkman
Role of Trafficking in the Regulation of CFTR Function
Raymond Frizzell
Role of CFTR and Its Interacting Partners in Cholera Toxin-Induced Diarrhea
Anjaparavanda Naren
KCNMA1 K Channels Mediate K-Dependent Intestinal Fluid Ssecretion: A Potential Anti-Secretory Target
Vazhaikkurichi Rajendran |
| 12:45 p.m. – 1:45 p.m. |
Working Lunch and Poster Session |
| 1:45 p.m. – 3:15 p.m. |
Session III A: PATHOPHYSIOLOGIC MECHANISMS (Continued)
Regulation of Intestinal Na Absorption: NHE3
Mark Donowitz
Regulation of Intestinal Chloride Absorption: SLC26 Transporters
Pradeep Dudeja
Pathways of Intestinal Epithelial Water Transport and Molecular Mechanisms of Its Regulation
Olga Kovbasnjuk
Calcium Sensing Receptor (CaSR) Regulation of Intestinal Ion Transporters
John Geibel
Primary Discussant
Fayez Ghishan
Panel Discussion |
| 3:15 p.m. – 3:30 p.m. |
BREAK |
| 3:30 p.m. – 5:30 p.m. |
Session III B: Paracellular Transport and Motility
Moderator: Jerrold Turner
Inflammatory Diarrhea: New Approaches to Drugging the Junction
Jerrold Turner
Mechanisms of Epithelial Barrier Disturbance in Inflammatory Bowel Disease
Joerg-Dieter Schulzke
Primary Discussant
James Anderson
Panel Discussion
Neuromuscular/Nerve-Gut, EC cells, Motility
Terez Shea-Donohue
Review of Enteroendocrine and Neuromuscular Mechanisms in the Pathophysiology of Acute Diarrhea
Michael Camilleri
Panel Discussion |
| 5:30 p.m. – 7:00 p.m. |
Session IV: Breakout Groups for Sessions I, II, IIIA, IIIB, and IV |
| |
|
Tuesday, September 27, 2011 |
| 8:30 a.m. – 8:40 a.m. |
Summary of Days 1 and 2
James Nataro and James Anderson |
| 8:40 a.m. – 10:00 a.m. |
Session V: Translation of Current Understanding of Pathophysiological Mechanisms into Potential Treatment Options
David Alpers
Developmental Strategy for Approaching Druggable Targets
Alan Verkman
Challenges of Drug Development for Diarrhea
David Brown
Development of a CFTR Inhibitor as a Potential Treatment for Acute Secretory Diarrhea
Tue Nguyen
Overview of NIH Molecular Libraries Program
Ronald Margolis
Primary Discussant
Henry J. Binder
Panel Discussion |
| 10:00 a.m. – 10:25 a.m. |
BREAK |
| 10:25 a.m. – 11:15 a.m. |
Session VI: Breakout Reports
Moderator: Mark Donowitz and Session Moderators |
| 11:15 a.m. – 12:15 p.m. |
Session VII: Final Discussion: Knowledge Gaps, Opportunities and Priorities
David Alpers |
| 12:15 p.m. – 12:30 p.m. |
Closing Remarks/Adjournment
Stephen James |
| |
|
| |
